How can I save money on my
LOTRONEX® prescription?

The LOTRONEX Savings Program may be able to help

This program has been designed to help you with the cost of your prescription. Don’t let cost stop you from getting the treatment that is right for you—learn more about the LOTRONEX Savings Program.

Here’s how it works:

  1. You pay up to the first $15 of either a copayment or out-of-pocket expenses
  2. The LOTRONEX Savings Program will then pay up to $500 of the balance
  3. Present your LOTRONEX Savings Program benefit card to your pharmacist each time you fill your LOTRONEX prescription

Once you are prescribed LOTRONEX, you may be eligible for the LOTRONEX Savings Program. Ask your prescribing doctor, or download the Savings Program Card, which can save you money on out-of-pocket payments.

This program is subject to eligibility. Restrictions apply. Patients must comply with the requirements of the Prescribing Program for LOTRONEX™ (PPL).

Before you fill your LOTRONEX prescription

Please call 1-888-445-9444 to activate the Savings Program card you receive from your doctor. Then all you have to do is present your LOTRONEX Savings Program benefit card to your pharmacist each time you fill your LOTRONEX prescription.

Before using LOTRONEX® for the first time, you should:

  • Understand that LOTRONEX has serious risks for some people.
  • Read and follow the directions in the Medication Guide.
  • Sign a Patient Acknowledgement Form.

LOTRONEX is a medicine only for some women with severe irritable bowel syndrome (IBS) whose main problem is diarrhea; whose IBS symptoms have lasted 6 months or longer and have not been helped enough by other treatments.

You can tell if your IBS is severe if at least 1 of these is true: you have lots of painful stomach cramps or bloating; you often cannot control the need to have a bowel movement, or you have “accidents” where your underwear gets dirty from diarrhea or bowel movements; you cannot lead a normal home or work life because you need to be near a bathroom.

Enough testing has not been done to confirm if LOTRONEX works in men or children under 18.


What are the most important facts I should know about LOTRONEX?

LOTRONEX can cause serious side effects:

Some patients have reported serious intestinal side effects while taking LOTRONEX. These include:

  • serious complications of constipation
  • reduced blood flow to the bowel (ischemic colitis)

These can happen suddenly and may lead to a hospital stay and, in rare cases, blood transfusions, surgery, and death.

Stop taking LOTRONEX and call your doctor right away if you have problems clearing your bowels (are constipated) or get new or worsening pain in your stomach area or blood in your stools. If your constipation does not get better after stopping LOTRONEX, call your doctor again. If you stopped taking LOTRONEX, do not start taking LOTRONEX again unless your doctor tells you to do so.

People who are older, who are weak from sickness, or who take other constipating medicines may be more likely to have serious complications of constipation with LOTRONEX.

There is a special prescribing program for LOTRONEX.

Only doctors who have signed up with the company that makes LOTRONEX should write prescriptions for LOTRONEX. These doctors have said that they understand about IBS and the possible side effects of LOTRONEX. Your doctor will ask you to sign a form after you read the LOTRONEX Medication Guide for the first time. Signing this form means that you understand the benefits and risks of LOTRONEX and that you have read and understand the Medication Guide.

Who should not take LOTRONEX?

Do not take LOTRONEX if any of these apply to you:

  • Your main IBS problem is constipation or you are constipated most of the time.
  • You have had a bad problem from constipation. If you are constipated now, do not start taking LOTRONEX.
  • You have had bad bowel blockages.
  • You have had blood flow problems to your bowels, such as ischemic colitis.
  • You have had blood clots.
  • You have had Crohn’s disease, sores in the colon (ulcerative colitis), swelling of a sac in the intestine (diverticulitis), or severe liver disease.
  • You do not understand the Medication Guide or the Patient Acknowledgement Form, or you are not willing to follow them.
  • You are taking a medicine called LUVOX® (fluvoxamine).

What are the possible side effects of LOTRONEX?

The most common side effects of LOTRONEX are constipation, stomach pain and nausea. These are not all the possible side effects of LOTRONEX. Your doctor or pharmacist can give you a more complete list. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit or call 1-800-FDA-1088.